医学博士，教授，博导，扬州大学转化医学研究院常务副院长，江苏省欧美同学会常务理事，扬州市欧美同学会副会长。中国中医药信息学会科技创新与成果转化分会常务理事，中国教育国际交流协会医学教育管理学科组专家，江苏省解剖学会期刊与教材专委会委员，江苏英国20+20高水平大学联盟医学专委会委员。入选江苏省“六大人才高峰”及省优秀留学回国人员。教育部首批国家级一流本科课程、国家级研究生在线重点建设课程、江苏高校省级外国留学生英文课程负责人。在国内外发表专业学术论文和教改论文80余篇。主持国家重点研发计划、自然科学基金等国家级科研项目5项。

主持课题：

1.心脑血管重重大疾病外国专家工作室，江苏省科学技术厅外专项目，2019.12-2022.11,4万元，主持。

2.基于转基因动物平台的动脉粥样硬化转化医学研究（No.G20190214041），科技部高端外国专家项目，2019.10-2021.9，10万元，主持。

3.应用基因修饰疾病动物模型的心脑血管转化医学研究（No.WSN-082)，江苏省“六大人才高峰”高层次人才培养项目，2018.10-2021.9，4万元，主持

4.基于转基因动物平台的心脑血管转化医学研究（No.2016YFE0126000），国家重点研发计划国际合作创新重点专项，2016.1-2020.12，269.86万元，主持。

5.利用转基因兔模型研究基质金属蛋白酶-9在动脉硬化斑块破裂中的作用（No.81570392），国家自然科学基金，2016.1-2019.12，84万，主持。

发表学术论文：

1.庄文雯,杨咏琪,李洪亮,梁景岩.动脉粥样硬化过程中核因子E2相关因子2对血管平滑肌细胞的调控作用[J].浙江大学学报(医学版),2021,50(03):390-395.

2.徐义君,符长标,梁景岩,唐铁钰,王英歌.1例成人抗N-甲基-D-天冬氨酸受体抗体合并抗髓鞘少突胶质细胞糖蛋白抗体双阳性脑炎病例报告[J].实用临床医药杂志,2021,25(11):47-49+53.

3.严坤宁,张婷,查艺闻,梁景岩,成勇.运用CRISPR/Cas9技术构建PCSK9点突变家兔模型[J].浙江大学学报(医学版),2021,50(02):229-238.

4.李鼎,王大新,梁景岩.长链非编码RNA在心血管疾病中的作用及机制[J].华中科技大学学报(医学版),2020,49(06):777-783.

5.袁媛,北山秋雄,胡俊飞,陈宏梅,冒鑫娥,郤丽娟,梁景岩.基于Kano模型的社区老年人远程护理服务需求分析[J].护理学杂志,2020,35(01):5-9.

6.陈宏梅,张松,王英歌,袁媛,唐向明,张新江,梁景岩.脑卒中神经疲劳指数量表的汉化及信效度评价[J].护理研究,2020,34(23):4135-4138.

7.查艺闻,梁景岩.中国人群载脂蛋白A5与动脉粥样硬化性心脑血管疾病[J].临床心血管病杂志,2020,36(10):965-969.

8.Zhai D, Xu Y, Abdelghany L, Zhang X, Liang J, Zhang S, Guo C, Li TS. Hydrostatic pressure stabilizes HIF‑1α expression in cancer cells to protect against oxidative damage during metastasis. Oncol Rep. 2021 Oct;46(4):211. doi:10.3892/or.2021.8162. Epub 2021 Aug 9. PMID: 34368876.

9.Li H, Zhuang W, Seo MS, An JR, Yang Y, Zha Y, Liang J, Xu ZX, Park WS. Inhibition of voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic agent lorcainide. Eur J Pharmacol. 2021 Aug 5;904:174158. doi: 10.1016/j.ejphar.2021.174158. Epub 2021 May 8. PMID: 33971179.

10.Yuan Y, Xu HW, Zhang S, Wang Y, Kitayama A, Takashi E, Gong WJ, Liang JY. The mediating effect of self-efficacy on the relationship between family functioning and quality of life among elders with chronic diseases. Nurs Open. 2021 May 7. doi: 10.1002/nop2.906. Epub ahead of print. PMID: 33960735.

11.Huang Y, Wang Y, Duan Z, Liang J, Xu Y, Zhang S, Tang T. Restored microRNA-326-5p Inhibits Neuronal Apoptosis and Attenuates Mitochondrial Damage via Suppressing STAT3 in Cerebral Ischemia/Reperfusion Injury. Nanoscale Res Lett. 2021 Apr 20;16(1):63. doi: 1186/s11671-021-03520-3. PMID: 33877455;PMCID: PMC8058131.

12.Yuan Y, Xue C, Wu Q, Wang M, Liu J, Zhang L, Xing Q, Liang J, Wu H, Chen Z. The miR-145-5p/CD36 pathway mediates PCB2-induced apoptosis in MCF-7 cells. Genes Genomics. 2021 Feb;43(2):161-171. doi: 10.1007/s13258-020-01025-4. Epub 2021 Jan 30. PMID: 33517563.

13.Ting Zhang, Rui Lu, Yibing Chen, Yuguo Yuan, Shaozheng Song, Kunning Yan, Yiwen Zha, Wenwen Zhuang, Yong Cheng* and Jingyan Liang*. Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9. Lipids in Health and Disease (2020) 19:224. doi.org/10.1186/s12944-020-01394-5

14.Yan H, Niimi M, Matsuhisa F, Zhou H, Kitajima S, Chen Y, Wang C, Yang X, Yao J, Yang D, Zhang J, Murakami M, Nakajima K, Wang Y, Liu E, Liang J, Chen YE, Fan J. Apolipoprotein CIII Deficiency Protects Against Atherosclerosis in Knockout Rabbits. Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2095-2107. doi: 10.1161/ATVBAHA.120.314368. Epub 2020 Aug 6.

15.Yuan Y, Liu Y, Gong L, Chen H, Zhang S, Kitayama A, Takashi E, Liang J. Demand analysis of telenursing for community-dwelling empty-nest elderly based on Kano model. Telemedicine and e-Health, 2020 Jun 2. doi: 10.1089/tmj.2020.0037.

16.Chen Y, Waqar AB, Nishijima K, Ning B, Kitajima K, Matsuhisa F, Chen L, Liu E, Zhang J, Chen YE, Liang J, Sun H, Fan J. Macrophage-derived MMP-9 enhances the progression of atherosclerotic lesions and vascular calcification in transgenic rabbits[J]. Journal of Cellular and Molecular Medicine 2020 Apr;24(7):4261-4274. doi: 10.1111/jcmm.15087. Epub 2020 Mar 3.

17.Tang X, Yan K, Wang Y, Wang Y, Chen H, Xu J, Lu Y, Wang X, Liang J, Zhang X. Activation of PPAR-β/δ Attenuates Brain Injury by Suppressing Inflammation and Apoptosis in a Collagenase-Induced Intracerebral Hemorrhage Mouse Model. Neurochem Res.(2020) 45:837–850. doi: 10.1007/s11064-020-02956-w. [Epub ahead of print]

18.Tang T, Duan Z, Xu J, Liang J, Zhang S, Zhang H, Zhang X, Wang Y. Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2-mediated AMPK/STAT3 pathway in an atherosclerosis rat model. Exp Ther Med. 2020 Jan;19(1):45-52. doi: 10.3892/etm.2019.8211. Epub 2019 Nov 18.

19.Wang C, Niimi M, Kitajima S, Matsuhisa F, Yan H, Dong S, Liang J, Fan J. Sex hormones affect endothelial lipase-mediated lipid metabolism and atherosclerosis. Lipids Health Dis. 2019 Dec 23;18(1):226. doi: 10.1186/s12944-019-1175-4.

20.梅笑雪,卢瑶瑶,梁景岩,王颖.利拉鲁肽对高脂血症小鼠脂代谢及氧化应激的影响[J].哈尔滨医药,2019,39(06):503-506.

21.钟港,孙雨婷,王梦恬,袁婷婷,卢瑶瑶,冯瑞玲,梁景岩. HMGB1与动脉粥样硬化相关疾病的研究进展[J].医学综述,2019,25(10):1873-1878.

22.张艳榕,高文菁,陈子旋,卢瑶瑶,梁景岩,王英歌. 南蛇藤素抗动脉粥样硬化机制的研究进展[J].医学综述,2019,25(02):375-379.

23.徐将,陈子旋,王英歌, 段作伟, 唐向明, 袁婷婷, 卢遥遥, 陈红梅, 严坤宁, 梁景岩, 张新江.血清miR-320b与急性缺血性卒中患者颈动脉粥样硬化的相关性[J].国际脑血管病杂志,2019,27(2):113-1

24.Xu J, Chen Z, Wang Y, Wang X, Chen L, Yuan T, Tang X, Lu Y, Chen H, Chen M, Duan Z, Fan J, Liang J, Zhang X. Several circulating miRNAs related to hyperlipidemia and atherosclerotic cardiovascular diseases. Lipids Health Dis. 2019 Apr 22;18(1):104. doi: 10.1186/s12944-019-1046-z.

25.Chen Y, Waqar AB, Yan H, Wang Y, Liang J, Fan J. Renovascular Hypertension Aggravates Atherosclerosis in Cholesterol-Fed Rabbits. J Vasc Res. 2019 Apr 4;56(1):28-38. doi: 10.1159/000498897.

26.Yuan T, Zhong Y, Wang Y, Zhang T, Lu R, Zhou M, Lu Y, Yan K, Chen Y, Hu Z, Liang J*, Fan J*, Cheng Y*. Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system. Lipids in Health and Disease 2019 Mar 18;18(1):69. doi: 10.1186/s12944-019-1013-8.

27.Fan J, Chen Y, Yan H, Liu B, Wang Y, Zhang J, Chen YE, Liu E, Liang J*. Genomic and Transcriptomic Analysis of Hypercholesterolemic Rabbits: Progress and Perspectives. Int J Mol Sci. 2018 Nov 8;19(11). pii: E3512. doi: 10.3390/ijms19113512.

28.Liang J, Chen L, Pan Y, Qian Y, Wei L, Zhang Y, He K, Liu Y, Wang Y. Systematic Understanding the Mechanisms of Tripterygium wilfordii on Atherosclerosis and Pharmacodynamics Research in Apo E‑/‑mice Model. Pharmacogn. Mag. 2018 Jul;58(14):624-633. DOI:10.4103/pm.pm_556_17

29.Lu R, Yuan T, Wang Y, Zhang T, Yuan Y, Wu D, Zhou M, He Z, Lu Y, Chen Y, Fan J, Liang J*, Cheng Y*. Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7. EBioMedicine. 2018 Oct;36:29-38. doi: 10.1016/j.ebiom.2018.09.020.

30.Wang C, Niimi M, Watanabe T, Wang Y, Liang J*, Fan J*. Treatment of atherosclerosis by traditional Chinese medicine: questions and quandaries[J]. Atherosclerosis. 2018 Oct;277:136-144. doi: 10.1016/j.atherosclerosis.2018.08.039.

31.Ning B, Chen Y, Waqar BW, Yan H, Shiomi M, Zhang J, Chen YE, Wang Y, Itabe H, Liang J, Fan J. Hypertension enhances advanced atherosclerosis and induces cardiac death in Watanabe heritable hyperlipidemic rabbits[J]. Am J Pathol. 2018 Dec; 188(12):2936-2947. doi: 10.1016/j.ajpath.2018.08.007.

32.Liang J, Wang W, Wei L, Gao S, Wang Y. Oridonin inhibits growth and induces apoptosis of human neurocytoma cells via the Wnt/β‑catenin pathway[J]. Oncol Lett. 2018 Aug 16: 3333-3340

33.Wang Y, Gao S, Wang W, Xia Y, Liang J. Downregulation of N‑Myc inhibits neuroblastoma cell growth via the Wnt/β‑catenin signaling pathway[J]. Mol Med Rep. 2018 Jul;18(1):377-384.

34.Fan J, Chen Y, Yan H, Niimi M, Wang Y, Liang J*. Principles and Applications of Rabbit Models for Atherosclerosis Researchs[J]. J Atheroscler Thromb. 2018 Mar 1;25(3):213-220. doi: 10.5551/jat.RV17018.

35.Wang Y, Chen L, Tian Z, Shen X, Wang X, Wu H, Wang Y, Zou J, Liang J*. CRISPR-Cas9 mediated gene knockout in human coronary artery endothelial cells reveals a pro-inflammatory role of TLR2. Cell Biol Int. 2018 Feb;42(2):187-193. doi: 10.1002/cbin.10885.

36.袁婷婷,周敏雅,卢瑶瑶,陆睿,张婷,孙雨婷,钟港,王梦恬,黄俊杰,胡艳华,梁景岩,成勇.利用CRISPR/Cas9技术制备ApoE~(-/-)兔[J].中国动脉硬化杂志,2018,26(07):658-665.

37.唐向明, 陈子旋, 王英歌, 陈宏梅, 徐将, 段作伟, 王小洪, 梁景岩, 张新江. 胶原酶诱导脑出血模型小鼠血肿周围组织ATP结合盒转运体A1表达的动态变化 [J]. 国际脑血管病杂志,2018,26(9): 689-695.

38.唐向明,王英歌,徐将,梁景岩,张新江.脑出血后脑白质损伤与修复[J].国际脑血管病杂志,2018,26(3):228-232.

39.张雨蒙,王柱,蔡子澍,陈露,徐将,梁景岩.易损斑块动物模型的研究进展[J].医学综述,2018,24(08):1457-1462.

40.王英歌,梁景岩*,陈露,潘阳,张雨蒙,何凯明.血浆前蛋白转化酶枯草溶菌素9与钙化性主动脉瓣疾病的关联机制[J].中国免疫学杂志,2018(03):403-406+411.

41.徐将,陈露,王小洪,张新江,梁景岩.脂质代谢相关microRNA概述[J].中国动脉硬化杂志,2018,26(01):103-108.

42.Wang Y, Liang J, Xu J, Wang X, Zhang X, Wang W, Chen L, Yuan T: Circulating exosomes and exosomal lncRNA HIF1A-AS1 in atherosclerosis. Int J Clin Exp Pathol 2017;10(8):8383-88. (SCI)

43.Zhang J, Niimi M, Yang D, Liang J, Xu J, Kimura T, Mattew AV, Guo Y, Fan Y, Zhu T, Song J, Ackermann R, Koike Y, Schwendeman A, Lai L, Pennathur S, Garcia-Barrio M, Fan J, Chen YE. Deficiency of Cholesteryl Ester Transfer Protein Protects Against Atherosclerosis in Rabbits. Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1068-1075. doi: 10.1161/ATVBAHA.117.309114. （SCI） 6.607

44.陈露, 袁婷婷, 徐将，梁景岩. 前蛋白转化酶枯草溶菌素9与动脉粥样硬化及斑块破裂的关系[J]. 医学综述, 2017,23(24):4785-90.

45.常淑文,三浦大志,北山秋雄,一志歩乃加,梁景岩,陈齐红,束余声,乔炎.八仙逍遥汤药浴对大鼠压力性损伤的预防和治疗效果[J].中华现代护理杂志,2017,(21):2714-2720. DOI:10.3760/cma.j.issn.1674-2907.2017.21.004. 科技核心

46.梁景岩, 陈露, 潘阳, 袁婷婷, 张雨蒙, 徐文华, 何凯明, 杨天立, 王英歌. 原花青素对动脉粥样硬化模型家兔MMP-9表达的影响[J]. 动物医学进展, 2017,38(10):88-91.

47.王英歌,陈露,张新江,梁景岩. 老年脑梗死患者血浆MMP-9、CD105和TIMP-1的表达水平及其与颈总动脉粥样硬化斑块稳定性的相关性[J]. 中国老年学杂志,2017,(37):2912-14.

48.Wang Y, Gao S, Wang W, Liang J. Temozolomide inhibits cellular growth and motility via targeting ERK signaling in glioma C6 cells. Mol Med Rep. 2016 Dec;14(6):5732-5738.

49.Wang Y, Wang W, Gao S, Wang L, Liang J. Laser Microdissection-based Analysis of Cytokine Balance in the Kidneys of Patients with ANCA-associated glomerulonephritis. Int J Clin Exp Pathol. 2016 Apr;9(2):1068-1080

50.Liang J, Kang D, Wang Y, Yu Y, Fan J, Takashi E. Carbonate ion-enriched hot spring water promotes skin wound healing in nude rats. PLoS One. 2015 Feb 11;10(2):e0117106. doi: 10.1371/journal.pone.0117106.

51.Li S, Liang J, Niimi M, Bilal Waqar A, Kang D, Koike T, Wang Y, Shiomi M, Fan J. Probucol suppresses macrophage infiltration and MMP expression in atherosclerotic plaques of WHHL rabbits. J Atheroscler Thromb. 2014;21(7):648-58.

52.Maruyama H, Watanabe S, Kimura T, Liang J, Nagasawa T, Onodera M, Aonuma K, Yamaguchi I. Granulocyte colony-stimulating factor prevents progression of monocrotaline-induced pulmonary arterial hypertension in rats. Circ J. 2007 Jan;71(1):138-43.

53.Liang J, Liu E, Yu Y, Kitajima S, Koike T, Jin Y, Morimoto M, Hatakeyama K, Asada Y, Watanabe T, Sasaguri Y, Watanabe S, Fan J. Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits. Circulation. 2006 Apr 25;113(16):1993-2001.

54.Ichikawa T, Liang J, Kitajima S, Koike T, Wang X, Sun H, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J. Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits. Atherosclerosis. 2005 Mar;179(1):87-95.

55.Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Sun H, Watanabe T, Liu G, Fan J. Enhanced aortic atherosclerosis in transgenic Watanabe heritable hyperlipidemic rabbits expressing lipoprotein lipase. Cardiovasc Res. 2005 Feb 1;65(2):524-34.

56.Wang X, Liang J, Koike T, Sun H, Ichikawa T, Kitajima S, Morimoto M, Shikama H, Watanabe T, Sasaguri Y, Fan J. Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits. Am J Pathol. 2004 Oct;165(4):1375-83.

57.Ichikawa T, Kitajima S, Liang J, Koike T, Wang X, Sun H, Okazaki M, Morimoto M, Shikama H, Watanabe T, Yamada N, Fan J. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Lab Invest. 2004 Jun;84(6):715-26.

58.Fan J, Wang X, Wu L, Matsumoto SI, Liang J, Koike T, Ichikawa T, Sun H, Shikama H, Sasaguri Y, Watanabe T. Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits. Transgenic Res. 2004 Jun;13(3):261-9.

59.Koike T, Liang J, Wang X, Ichikawa T, Shiomi M, Liu G, Sun H, Kitajima S, Morimoto M, Watanabe T, Yamada N, Fan J. Overexpression of lipoprotein lipase in transgenic Watanabe heritable hyperlipidemic rabbits improves hyperlipidemia and obesity. J Biol Chem. 2004 Feb 27;279(9):7521-9.

60.Sun H, Unoki H, Wang X, Liang J, Ichikawa T, Arai Y, Shiomi M, Marcovina SM, Watanabe T, Fan J. Lipoprotein(a) enhances advanced atherosclerosis and vascular calcification in WHHL transgenic rabbits expressing human apolipoprotein(a). J Biol Chem. 2002 Dec 6;277(49):47486-92.

61.Koike T, Wang X, Unoki H, Liang J, Ichikawa T, Kitajima S, Watanabe T, Fan J. Increased expression of lipoprotein lipase in transgenic rabbits does not lead to abnormalities in skeletal and heart muscles. Muscle Nerve. 2002 Dec;26(6):823-7.

62.Sakai Y, Kim DK, Iwasa S, Liang J, Watanabe T, Onodera M, Nakauchi H. Bone marrow chimerism prevents atherosclerosis in arterial walls of mice deficient in apolipoprotein E. Atherosclerosis. 2002 Mar;161(1):27-34.

登记软件著作权：

1.疾病模式动物数据整合分析软件V1.0，梁景岩等，2019.10.1，中国，登记号：2020SR0055777

2.重大疾病动物评价体系V1.0，梁景岩等，2019.10.1，中国，登记号：2020SR0055607

科研获奖：

1.华东地区解剖学青年科学家奖 -应用转基因动物的转化医学研究，排名第一，2017年，华东六省一市解剖学会

2.特别研究员奖-非侵入生体内不稳定斑块NO探针的研发，排名第一，2007年，日本学术振兴会

3.国际青年研究者奖--基质金属蛋白酶12在动脉硬化进展中的作用，排名第一，2006年.日本循环学会